T Cell Movement in Lymph nodes
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links-own [ tDCfree ] globals [ dt ds tcell-step nDCmeet ] ; ... ; nDCmeet = number of DC-T cell encounters breed [tcells tcell] ; the T cells breed [DCs DC] ; the dendritic cells (DCs) to setup clear-all set-default-shape turtles "circle" ; all turtles will be circles (spheres) create-tcells 100 [ set color green ; make T cell green setxyz random-xcor random-ycor random-zcor ; put T cell at random location ] create-DCs 2 [ set size 2 ; make DC of size 2 (twice that of T cells) set color red ; make DC red setxyz random-xcor random-ycor random-zcor ] set dt 0.5 ; 0.5 min per time step set ds 8 ; 8 um per patch set tcell-step 16 / ds * dt ; (16 um/min)*(1 patch/8 um)*(0.5 min/time step) end to go move-tcells ; move T cell movement commands into a function identify-DCbound-tcells ; new function to identify DC-bound T cells update-link-status ; new function to update DC-T cell links plotxy ticks nDCmeet tick-advance dt end to move-tcells ; function for T cell motion ask tcells [ right random-normal 0 90 roll-right random-normal 0 90 forward tcell-step ] end to identify-DCbound-tcells ; function to identify DC-bound T cells ask DCs [ create-links-to tcells with [ color != blue ] in-radius 2 [ set nDCmeet nDCmeet + 1 set color red ; make the link red set tDCfree 3 ; bound for 3 minutes ask end2 [ set color blue ] ; make the linked T cell blue ] ] end to update-link-status ; function to update the DC-T cell links ask links [ set tDCfree tDCfree - dt ; update time remaining for link if tDCfree < 0 [ ; if tDCfree has elapsed ask end2 [ set color green ] ; set T cell to its green colour die ; kill the link (delete it) ] ] end
There is only one version of this model, created 7 months ago by Haeden Graewe.
Attached files
File | Type | Description | Last updated | |
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T Cell Movement in Lymph nodes.png | preview | Preview for 'T Cell Movement in Lymph nodes' | 7 months ago, by Haeden Graewe | Download |
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