GvHD and Tregs
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breed [grafts graft] grafts-own [stuck energy] breed [tregs treg] breed [tcells tcell] tcells-own [bound activated] to setup clear-all create-tcells 200 [ set shape "dot" set color red setxy random-xcor random-ycor set bound nobody set activated true ] if mode != "start without graft" [add-grafts] setup-membrane reset-ticks end to go mode-go tcells-go grafts-go tregs-go tick end to mode-go (ifelse mode = "regular dosage" [if ticks mod 1000 = 1 [add-tregs] ] ) end to revert-defaults set treg-death 0.0020 set tcell-reactivation 0.003 set treg-dosage 50 end to setup-membrane ask patches [set pcolor 134] ask patches with [abs pycor = max-pycor] [set pcolor 138] end to add-grafts create-grafts 40 [ set shape "dot" set size 4 set color 19 setxy random-xcor max-pycor if random 2 = 1 [set ycor min-pycor] set stuck true ] end to tcells-go ask tcells [ ifelse bound = nobody [ lt 30 - random 60 ;try not to stick to walls if pycor = max-pycor [set heading 180] if pycor = min-pycor [set heading 0] fd 0.5 ifelse activated [ let my-graft one-of grafts-here if my-graft != nobody[ set bound my-graft ] ] [ ; if unactivated, stochastic chance to be activated if random-float 1 < tcell-reactivation [set activated true set color red] ] ] [ifelse activated [ move-to bound set heading random 360 fd random-float 0.3 ] [set bound nobody] ] ] end to grafts-go ask grafts [ set energy count tcells-here in-radius 1 with [activated] set color 19 - energy if energy >= 4 [set stuck false] if energy >= 10 [die] if not stuck [ lt 30 - random 60 fd 0.25 ifelse energy = 0 [ if pycor = max-pycor [set ycor pycor set stuck true] if pycor = min-pycor [set ycor pycor set stuck true] ] [ ;try not to stick to walls if pycor = max-pycor [set heading 180] if pycor = min-pycor [set heading 0] ] ] ] end to add-tregs create-tregs treg-dosage [ set color sky ] end to tregs-go ask tregs[ lt 30 - random 60 fd 0.25 ;try not to stick to walls if pycor = max-pycor [set heading 180] if pycor = min-pycor [set heading 0] if any? tcells in-radius 1 [ ask tcells in-radius 1 [ set activated false set color 18 ] ] if random-float 1 < treg-death [die] ] end
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