Sleep-Wake_Regulation-Model 01_01

Sleep-Wake_Regulation-Model 01_01 preview image

1 collaborator

Tags

neurophysiology/medicine 

Tagged by Victor Iapascurta over 1 year ago

sleep, sleep regulation 

Tagged by Victor Iapascurta over 1 year ago

Visible to everyone | Changeable by the author
Model was written in NetLogo 6.0.1 • Viewed 312 times • Downloaded 14 times • Run 0 times
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How to make the model run

It looks like import-drawing primitive is not supported. In order to run the model without the brain image the code should be changed and recompiled. After activating "Run in NetLogo Web" and "Click to Run the Model" the line # 48 in the code should be erased/deactivated and the code recompiled by pressing the respective button. After this the model can be run. Sorry for inconvenience. Author of the model

Posted over 1 year ago

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globals [
          fc-network
          mc-network
          pc-network
          lc-network
          vlpo-network
          th-network
          dr-network
          ldt-ppt-network
          ox-network

          sleep-propencity?
          main-patches
          edge-patches
          ]

breed [fc-neurons fc-neuron]
breed [mc-neurons mc-neuron]
breed [pc-neurons pc-neuron]
breed [lc-neurons lc-neuron]
breed [vlpo-neurons vlpo-neuron]
breed [th-neurons th-neuron]
breed [dr-neurons dr-neuron]
breed [ldt-ppt-neurons ldt-ppt-neuron]
breed [ox-neurons ox-neuron]

breed [nodes node]
breed [impulses impulse]
breed [spinners spinner]

undirected-link-breed [rf-links rf-link]
undirected-link-breed [slinks slink]
directed-link-breed [red-links red-link]
directed-link-breed [green-links green-link]

patches-own [ adenozin ]
impulses-own [location]

to setup

 clear-turtles
 clear-patches
 clear-links
 clear-all-plots
 clear-drawing

 import-drawing "Sleep-Wake_Regulation-M01_01.png"

 create-fc-network
 create-mc-network
 create-pc-network
 create-lc-network
 create-vlpo-network
 create-th-network
 create-dr-network
 create-ldt-ppt-network
 create-ox-network
 create-spinner

 ask turtles [ set adenozin random 0.1 ]
 recolor-patches

 ask patches at-points [[7 -11] [0 0] [2 3] [2 -16] [8 -21]]
  [ sprout-nodes 1
    [
    set shape "circle"
    set size 3
     ht
    ]
  ]

  ask nodes [
    create-rf-link-with one-of other nodes
  ]

  create-impulses 5 [
    set shape "circle"
    set size 1
    set color yellow
    set location one-of nodes
    move-to location
  ]
  set edge-patches patches with [count neighbors != 8]
  set main-patches patches with [count neighbors = 8]

   ask spinners [setxy -40 -40]

   reset-ticks
end 

to create-fc-network
   create-fc-neurons  20 [
      set shape "circle"
      set color yellow
    set size 1.5
  ]
  set fc-network patches with [
        pxcor > ( - 38 ) and
        pxcor <  ( - 27 ) and
        pycor > 0 and
        pycor < 27
      ]

  ask fc-neurons [move-to one-of fc-network
  ]
end 

to create-mc-network
   create-mc-neurons  30 [
      set shape "circle"
      set color yellow
    set size 1.5
  ]
  ask one-of mc-neurons [ set label "Cortex" ]

  set mc-network patches with [
        pxcor > ( - 20 ) and
        pxcor < 20 and
        pycor > 20 and
        pycor < 37
      ]


   ask mc-neurons [move-to one-of mc-network]
end 

to create-pc-network
   create-pc-neurons  40 [
      set shape "circle"
      set color yellow
    set size 1.5
  ]

  set pc-network patches with [
        pxcor > 18 and
        pxcor < 38 and
        pycor > ( - 2) and
        pycor < 24
      ]

   ask pc-neurons [move-to one-of pc-network]
end 

to create-lc-network
   create-lc-neurons 1 [
      set shape "elipce"
      set color violet
      set size 7
      set heading (- 10)
      set label "LC"
  ]

  set lc-network patches with [
        pxcor >  6  and
        pxcor < 9 and
        pycor > ( - 20 ) and
        pycor < ( - 18)
      ]

   ask lc-neurons [move-to one-of lc-network]
end 

to create-vlpo-network
      create-vlpo-neurons 2 [
      set shape "circle"
      set color green
      set size 3
     ]
     ask one-of vlpo-neurons [ set label "VLPO" ]

  set vlpo-network patches with [
        pxcor > ( - 8 ) and
        pxcor < ( - 6 ) and
        pycor > ( - 5 ) and
        pycor < 0
      ]

   ask vlpo-neurons [move-to one-of vlpo-network]
end 

to create-th-network
   create-th-neurons 7 [
      set shape "circle"
      set color orange
    set size 2
  ]
   ask one-of th-neurons [ set label "Thalamus" ]

  set th-network patches with [
        pxcor > ( - 6 ) and
        pxcor < 8 and
        pycor > 2 and
        pycor < 12
      ]

   ask th-neurons [move-to one-of th-network]
end 

to create-dr-network
   create-dr-neurons  1 [
      set shape "circle"
      set color magenta
      set size 2.5
      set label "DR"
     ]
  set dr-network patches with [
        pxcor > 1 and
        pxcor <  3 and
        pycor > (-17) and
        pycor < (-15 )
      ]

  ask dr-neurons [ move-to one-of dr-network ]
end 

to create-ldt-ppt-network
   create-ldt-ppt-neurons  1 [
      set shape "circle"
      set color pink
      set size 2.5
      set label "LDT/PPT"
     ]
  set ldt-ppt-network patches with [
        pxcor > 6 and
        pxcor <  8 and
        pycor > ( - 12 ) and
        pycor < ( - 10 )
      ]

  ask ldt-ppt-neurons [move-to one-of ldt-ppt-network
  ]
end 

to create-ox-network
   create-ox-neurons 3
   [
    set shape "pentagon"
    set color yellow
    set size 2
    set label "Orexin"
  ]
  set ox-network patches with [
        pxcor > 1 and
        pxcor < 2 and
        pycor > 3 and
        pycor < 4
      ]
end 

to go

  cycle-s-propencity
  diffuse adenozin 0.7
  recolor-patches
  update-spinner
  tick
end 

to run-wake-state

   if not any? fc-neurons [stop]
   ask one-of fc-neurons [
    create-slink-with one-of other fc-neurons
  ]
  while [ count slinks > 30 ]
  [ ask one-of slinks [ die ]
  ]

    if not any? mc-neurons [stop]
   ask one-of mc-neurons [
    create-slink-with one-of other mc-neurons
  ]
  while [ count slinks > 50 ]
  [ ask one-of slinks [ die ]
  ]

    if not any? pc-neurons [stop]
   ask one-of pc-neurons [
    create-slink-with one-of other pc-neurons
  ]
  while [ count slinks > 60 ]
  [ ask one-of slinks [ die ]
  ]

   if not any? th-neurons [stop]
   ask one-of th-neurons [
    create-slink-with one-of other th-neurons
  ]
  while [ count slinks > 15 ]
  [ ask one-of slinks [ die ]
  ]

   ask one-of th-neurons [
    create-red-link-to one-of pc-neurons
       ]
  ask red-links [
    set color red
    set thickness 0.2
  ]

  while [ count red-links > 3 ]
  [ ask one-of red-links [ die ]
  ]
   ask one-of th-neurons [
  create-red-link-to one-of mc-neurons
       ]
  ask red-links [
    set color red
    set thickness 0.2
  ]

  while [ count red-links > 3 ]
  [ ask one-of red-links [ die ]
  ]
    ask one-of th-neurons [
    create-red-link-to one-of fc-neurons
       ]
    ask red-links [
    set color red
    set thickness 0.2
  ]

  while [ count red-links > 3 ]
  [ ask one-of red-links [ die ]
  ]

  ask green-links [die]

  ask turtles [
    set adenozin random 0.1 + 0.5  ]

  ask rf-links [ set thickness 0
                 set color yellow]
  ask impulses [
                 let new-location one-of [rf-link-neighbors] of location
                 ask [rf-link-with new-location] of location [ set thickness 1 ]
                 face new-location
                 move-to new-location
                 set location new-location
               ]

 if (scenario = "Normal") and ( round sum [adenozin] of patches ) >= 1000
    [ set sleep-propencity? true]

 if (scenario = "Sleep-deprivation") and (( round sum [adenozin] of patches ) >= 1500)
    [ set sleep-propencity? true
      set scenario  "Normal" ]
end 

to recolor-patches

  ask patches [ set pcolor scale-color red adenozin 0 1 ]
end 

to run-sleep-state

  ask turtles [set adenozin adenozin - 0.2]
  ask impulses [stop]

  ask rf-links [set thickness 0]
  ask slinks [die]
  ask red-links [die]

  if not any? vlpo-neurons [stop]
  ask one-of vlpo-neurons [
  create-green-link-to one-of lc-neurons
  ]

  ask one-of vlpo-neurons [
                           create-green-link-to one-of DR-neurons
                          ]

  ask one-of vlpo-neurons [
                           create-green-link-to one-of ldt-ppt-neurons
                          ]

  ask one-of vlpo-neurons [
                           create-green-link-to one-of ox-neurons
                          ]

    ask green-links [
    set color green
    set thickness 0.7 ]
    while [ count green-links > 3 ]
    [ ask one-of green-links [ die ]
    ]

  ask edge-patches [ set adenozin 0 ]
  repeat 100 [ ask edge-patches [ set adenozin 0 ]]
  ifelse round sum [adenozin] of patches <= 0
  [set sleep-propencity? false]
  [set sleep-propencity? true]
end 

to cycle-s-propencity
   ifelse (sleep-propencity? = false) [
    run-wake-state
  ][
    run-sleep-state
  ]
end 

to create-spinner
  create-spinners 1 [
    set shape "clock"
    set color gray - 1.5
    set size 15
    set heading -0
    set label 0
    set label-color green
    ]
end 

to update-spinner
    ask spinners [
    set heading ticks * 10
    set label ticks
    set adenozin adenozin - 0.3
  ]
end 

There is only one version of this model, created over 1 year ago by Victor Iapascurta.

Attached files

File Type Description Last updated
Sleep-Wake_Regulation-Model 01_01.png preview preview file over 1 year ago, by Victor Iapascurta Download
SM_RM2.jpg jpeg preview over 1 year ago, by Victor Iapascurta Download

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